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pentobarbital will minimize the level or influence of cobimetinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Steer clear of coadministration. Solid or moderate CYP3A inducers might lessen cobimetinib systemic exposure by >80% and cut down its efficacy.pentobarbital and olopatadine intranasal both maximize sedation.

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